States have responded to increasing health care consolidation by enhancing their review of mergers and acquisitions. But some states have carved out certain academic medical centers from such ...

Recent changes in U.S. vaccine policy are sowing confusion and threatening the health of children and the wider population. How should pediatric clinicians communicate with parents to stem the damage?

Medical evidence comes in the form of population statistics, but patients behave like people, each one unique. Physicians walk the line, studying bell curves but hoping each intervention has an ...

Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic ...

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 3).

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 23).

To the Editor: Morin and Buysse (July 18 issue) 1 provide a comprehensive overview of current assessments and treatments for insomnia. Their emphasis on cognitive behavioral therapy for insomnia as a ...

Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C (N Engl J Med 2023;389:2125-2139). As a result of late data entry, a reanalysis using a later data snapshot (March ...

A 44-year-old woman with recurrent oral aphthous ulcers presented with a progressively worsening papulopustular rash on her face and legs. Skin biopsy of a leg lesion revealed focal small-vessel va ...

To the Editor: Sanyal et al. (Oct. 21 issue)1 add important new data to our understanding of the natural course of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH). A substa ...