Jul 24, 2025 · Pyrogenicity refers to the ability of a substance to induce a fever when it enters the body. While fever is a common response to various illnesses, pyrogenicity poses a specific concern in …

9. When is the USP Chapter <151> Pyrogenicity Test (the rabbit pyrogen test) appropriate? For certain biological products, 21 CFR 610.13 (b) requires a rabbit pyrogen test.

Understand pyrogenicity: the biological process of fever and critical safety testing required for medical products and pharmaceuticals.

Mar 5, 2025 · Pyrogenicity (from pyro, fire) is the ability of a substance to produce a febrile (fever) response. In humans, pyrogenic responses result from the role of Toll-Like Receptors (TLRs).

Pyrogenicity is associated with microbiological contamination of parenteral products, including those that have been sterilized, biosynthetically produced materials, vaccines and adjuvants, and medical …

The meaning of PYROGENICITY is the quality or state of being pyrogenic; especially : capacity to produce fever.

These are the analytical methods most commonly used to address the pyrogenicity of medicinal products administered parenterally. They present the great advantage of avoiding the use of …

Pyrogenicity is the capacity of a substance to induce a febrile (fever) response when introduced into the bloodstream, lymphatic system, or cerebrospinal fluid of an organism.

Nov 8, 2025 · Pyrogenicity is the ability of substances, both external and internal, to induce a fever by activating the body's immune system, which releases cytokines that raise the hypothalamic …

According to Ph. Eur., the decision to use the test for bacterial endotoxins as the sole pyrogenicity test should be made after careful evaluation of the risk of the substance or product containing non …